Substantive medical research can be extremely valuable in preparing a traumatic brain injury or toxic brain injury case. As a service to our legal clients, we have created an extensive bibliography of important research utilizing brain SPECT imaging in the evaluation of traumatic brain injury and carbon monoxide poisoning. This bibliography is composed of numerous published research article titles, with links to the abstracts, which our medical imaging experts have deemed most significant in assisting you with litigating brain injury cases.

Research on SPECT and Traumatic Brain Injury
1.  Abdel-Dayem HM, Abu-Judeh H, Kumar M, Atay S, Naddaf S, El-Zeftawy H, Luo JQ (1998) SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury. Clin Nucl Med 23: 309-317   www.ncbi.nlm.nih.gov/pubmed/9596157?dopt=Citation

2.  Abu-Judeh HH, Singh M, Masdeu JC, Abdel-Dayem HM (1998) Discordance between FDG uptake and technetium-99m-HMPAO brain perfusion in acute traumatic brain injury. J Nucl Med 39: 1357-1359
www.ncbi.nlm.nih.gov/pubmed/9708506?dopt=Citation

3.  Abu-Judeh HH, Parker R, Singh M, El-Zeftawy H, Atay S, Kumar M, Naddaf S, Aleksic S, Abdel-Dayem HM (1999) SPET brain perfusion imaging in mild traumatic brain injury without loss of consciousness and normal computed tomography. Nuclear Medicine Communications 20: 505-510   www.ncbi.nlm.nih.gov/pubmed/10451861?dopt=Citation 

4.  Abu-Judeh HH, Parker R, Aleksic S, Singh ML, Naddaf S, Atay S, Kumar M, Omar W, El-Zeftawy H, Luo JQ, Abdel-Dayem HM (2000) SPECT brain perfusion findings in mild or moderate traumatic brain injury. Nucl Med Rev.Cent.East Eur. 3: 5-11
www.ncbi.nlm.nih.gov/pubmed/14600973?dopt=Citation

5.  Assadi M, Eftekhari M, Gholamrezanezhad A (2007) SPET brain scan with (99m)Tc-ECD and CT, MRI in traumatic brain injury with chronic symptoms. Hell.J.Nucl.Med. 10: 183
www.ncbi.nlm.nih.gov/pubmed/18084662?dopt=Citation

6.  Audenaert K, Jansen HM, Otte A, Peremans K, Vervaet M, Crombez R, de Ridder L, Van Heeringen C, Thirot J, Dierckx R, Korf J (2003) Imaging of mild traumatic brain injury using 57Co and 99mTc HMPAO SPECT as compared to other diagnostic procedures. Med Sci.Monit. 9: MT112-MT117   www.ncbi.nlm.nih.gov/pubmed/14523337?dopt=Citation

7.  Belanger HG, Vanderploeg RD, Curtiss G, Warden DL (2007) Recent neuroimaging techniques in mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 19: 5-20
www.ncbi.nlm.nih.gov/pubmed/17308222?dopt=Citation

8.  Bigler ED (1999) Neuroimaging in pediatric traumatic head injury: diagnostic considerations and relationships to neurobehavioral outcome. J Head Trauma Rehabil. 14: 406-423
www.ncbi.nlm.nih.gov/pubmed/10407213?dopt=Citation

9.  Bigler ED (2003) Neurobiology and neuropathology underlie the neuropsychological deficits associated with traumatic brain injury. Archives of Clinical Neuropsychology 18: 595-621 
www.ncbi.nlm.nih.gov/pubmed/14591434?dopt=Citation

10. Chiu Wong SB, Chapman SB, Cook LG, Anand R, Gamino JF, Devous MD Sr (2006) A SPECT study of language and brain reorganization three years after pediatric brain injury. Prog.Brain Res. 157: 173-185
www.ncbi.nlm.nih.gov/pubmed/17167907?dopt=Citation

11. Coetzer BR (2004) Obsessive-compulsive disorder following brain injury: a review. International Journal of Psychiatry Medicine 34: 363-377
www.ncbi.nlm.nih.gov/pubmed/15825585?dopt=Citation

12. Coles JP. Imaging after brain injury. British Journal of Anaesthesia 99 (1), 49-60. 2007.
www.ncbi.nlm.nih.gov/pubmed/17573394?dopt=Citation

13. Davalos DB, Bennett TL (2002) A review of the use of single-photon emission computerized tomography as a diagnostic tool in mild traumatic brain injury. Appl.Neuropsychol. 9: 92-105
www.ncbi.nlm.nih.gov/pubmed/12214827?dopt=Citation

14. Donnemiller E, Brenneis C, Wissel J, Scherfler C, Poewe W, Riccabona G, Wenning GK (2000) Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPECT study using 123I-beta-CIT and 123I-IBZM. Eur.J Nucl Med 27: 1410-1414
www.ncbi.nlm.nih.gov/pubmed/11007526?dopt=Citation

15.  Dubroff JG, Newberg A (2008) Neuroimaging of traumatic brain injury. Semin.Neurol. 28: 548-557
www.ncbi.nlm.nih.gov/pubmed/18843581?dopt=Citation

16.  Eftekhari M, Assadi M, Kazemi M, Saghari M, Mojtahedi A, Fard-Esfahani A, Sichani BF, Beiki D (2006) Brain perfusion single photon emission computed tomography findings in patients with posttraumatic anosmia and comparison with radiological imaging. Am.J.Rhinol. 20: 577-581 
www.ncbi.nlm.nih.gov/pubmed/17181096?dopt=Citation

17.  Emanuelson IM, von Wendt L, Bjure J, Wiklund LM, Uvebrant P (1997) Computed tomography and single-photon emission computed tomography as diagnostic tools in acquired brain injury among children and adolescents. Developmental Medicine and Child Neurology 39: 502-507  
www.ncbi.nlm.nih.gov/pubmed/9295844?dopt=Citation

18.  Fann JR, Burington B, Lenonetti A, Jaffe K, Katon WJ, Thompson RS (2004) Psychiatric illness following traumatic brain injury in an adult health maintenance organization population. Archives of General Psychiatry 61: 53-61 
www.ncbi.nlm.nih.gov/pubmed/14706944?dopt=Citation

19.  Furlow B (2006) Diagnostic imaging of traumatic brain injury. Radiol.Technol. 78: 145-156
www.ncbi.nlm.nih.gov/pubmed/17119180?dopt=Citation

20.  Gallagher CN, Hutchinson PJ, Pickard JD (2007) Neuroimaging in trauma. Curr.Opin.Neurol. 20: 403-409 
www.ncbi.nlm.nih.gov/pubmed/17620874?dopt=Citation

21.  Garada B, Klufas RA, Schwartz RB (1997) Neuroimaging in Closed Head Injury. Seminars in Clinical Neuropsychiatry 2: 188-195
www.ncbi.nlm.nih.gov/pubmed/10320460?dopt=Citation

22.  Gerberding JL and Binder S. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem.  9-1-2003.  National Center for Injury Protection & Control.
www.cdc.gov/ncipc/tbi/mtbi/report.htm

23.  Goethals I, Audenaert K, Jacobs F, Lannoo E, Van de Wiele C, Ham H, Otte A, Oostra K, Dierckx R (2004) Cognitive neuroactivation using SPECT and the Stroop Colored Word Test in patients with diffuse brain injury. Journal of Neurotrauma 21: 1059-1069  
www.ncbi.nlm.nih.gov/pubmed/15319005?dopt=Citation

24.  Goshen E, Zwas ST, Shahar E, Tadmor R (1996) The role of 99Tcm-HMPAO brain SPET in paediatric traumatic brain injury. Nuclear Medicine Communications 17: 418-422   
www.ncbi.nlm.nih.gov/pubmed/8736519?dopt=Citation

25.  Gowda NK, Agrawal D, Bal C, Chandrashekar N, Tripati M, Bandopadhyaya GP, Malhotra A, Mahapatra AK (2006) Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. AJNR Am J Neuroradiol. 27: 447-451  
www.ncbi.nlm.nih.gov/pubmed/16484427?dopt=Citation

26.  Gray BG, Ichise M, Chung DG, Kirsh JC, Franks W (1992) Technetium-99m-HMPAO SPECT in the evaluation of patients with a remote history of traumatic brain injury: a comparison with x-ray computed tomography. J Nucl Med 33: 52-58
www.ncbi.nlm.nih.gov/pubmed/1730996?dopt=Citation

27.  Hendler T, Gross R, Goshen E, Faibel M, Hirshmann S, Zwass TS, Grunhaus L, Zohar J (1997) [Brain imaging and its clinical application in psychiatry]. Harefuah 133: 337-42, 416 
www.ncbi.nlm.nih.gov/pubmed/9418330?dopt=Citation

28.  Ichise M, Chung DG, Wang P, Wortzman G, Gray BG, Franks W (1994) Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance. J Nucl Med 35: 217-226 
www.ncbi.nlm.nih.gov/pubmed/8294988?dopt=Citation

29.  Ito H, Ishii K, Onuma T, Kawashima R, Fukuda H (1997) Cerebral perfusion changes in traumatic diffuse brain injury; IMP SPECT studies. Annals of Nuclear Medicine 11: 167-172     
www.ncbi.nlm.nih.gov/pubmed/9212901?dopt=Citation

30.  Jacobs A, Put E, Ingels M, Bossuyt A (1994) Prospective evaluation of technetium-99m-HMPAO SPECT in mild and moderate traumatic brain injury. J Nucl Med 35: 942-947  
www.ncbi.nlm.nih.gov/pubmed/8195879?dopt=Citation

31.  Kemp S, Goulding P, Spencer J, Mitchell AJ (2005) Unusually rapid and severe cognitive deterioration after mild traumatic brain injury. Brain Inj. 19: 1269-1276   
www.ncbi.nlm.nih.gov/pubmed/16286343?dopt=Citation

32.  Kimberley TJ, Lewis SM (2007) Understanding neuroimaging. Phys.Ther. 87: 670-683
www.ncbi.nlm.nih.gov/pubmed/17429004?dopt=Citation

33.  Kinuya K, Kakuda K, Nobata K, Sakai S, Yamamoto K, Itoh S, Ohashi M, Kinuya S (2004) Role of brain perfusion single-photon emission tomography in traumatic head injury. Nucl.Med.Commun. 25: 333-337 
www.ncbi.nlm.nih.gov/pubmed/15097806?dopt=Citation

34.  Kirkness CJ (2005) Cerebral blood flow monitoring in clinical practice. AACN.Clin.Issues 16: 476-487
www.ncbi.nlm.nih.gov/pubmed/16269893?dopt=Citation

35.  Laatsch L, Jobe T, Sychra J, Lin Q, Blend M (1997) Impact of cognitive rehabilitation therapy on neuropsychological impairments as measured by brain perfusion SPECT: a longitudinal study. Brain Injury 11: 851-863 
www.ncbi.nlm.nih.gov/pubmed/9413619?dopt=Citation

36.  Laatsch L, Pavel D, Jobe T, Lin Q, Quintana JC (1999) Incorporation of SPECT imaging in a longitudinal cognitive rehabilitation therapy programme. Brain Injury 13: 555-570 
www.ncbi.nlm.nih.gov/pubmed/10901685?dopt=Citation

37.  Lewine JD, Davis JT, Bigler ED, Thoma R, Hill D, Funke M, Sloan JH, Hall S, Orrison WW (2007) Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil. 22: 141-155  
www.ncbi.nlm.nih.gov/pubmed/17510590?dopt=Citation

38.  Lewis DH, Bluestone JP, Savina M, Zoller WH, Meshberg EB, Minoshima S (2006) Imaging cerebral activity in recovery from chronic traumatic brain injury: a preliminary report. J Neuroimaging 16: 272-277  
www.ncbi.nlm.nih.gov/pubmed/16808830?dopt=Citation

39.  Lorberboym M, Lampl Y, Gerzon I, Sadeh M (2002) Brain SPECT evaluation of amnestic ED patients after mild head trauma. The American Journal of Emergency Medicine 20: 310-313  
www.ncbi.nlm.nih.gov/pubmed/12098178?dopt=Citation

40.  Lorberboym M, Gilad R, Gorin V, Sadeh M, Lampl Y (2002) Late whiplash syndrome: correlation of brain SPECT with neuropsychological tests and P300 event-related potential. J Trauma 52: 521-526  
www.ncbi.nlm.nih.gov/pubmed/11901329?dopt=Citation

41.  Loutfi I, Singh A (1995) Comparison of quantitative methods for brain single photon emission computed tomography analysis in head trauma and stroke. Invest Radiol. 30: 588-594  
www.ncbi.nlm.nih.gov/pubmed/8557498?dopt=Citation

42.  Mahmutyazicioglu K, Ogawa T (2005) Remote effect of optic tract trauma in the occipital lobe (case report). Diagn.Interv.Radiol. 11: 19-22  
www.ncbi.nlm.nih.gov/pubmed/15795838?dopt=Citation

43.  Mann NM, Vento JA (2006) A study comparing SPECT and MRI in patients with anosmia after traumatic brain injury. Clin Nucl Med 31: 458-462  
www.ncbi.nlm.nih.gov/pubmed/16855430?dopt=Citation

44.  Masdeu JC, Abdel-Dayem H, Van Heertum RL (1995) Head trauma: use of SPECT. Journal of Neuroimaging 5: S53-S57
www.ncbi.nlm.nih.gov/pubmed/7626838?dopt=Citation

45.  Mauri M, Sinforiani E, Bono G, Cittadella R, Quattrone A, Boller F, Nappi G (2006) Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairment. Funct.Neurol. 21: 223-228   
www.ncbi.nlm.nih.gov/pubmed/17367583?dopt=Citation

46.  Mazzini L, Campini R, Angelino E, Rognone F, Pastore I, Oliveri G (2003) Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome. Arch Phys.Med Rehabil. 84: 1637-1641
www.ncbi.nlm.nih.gov/pubmed/14639563?dopt=Citation

47.  McGoron AJ, Capille M, Georgiou MF, Sanchez P, Solano J, Gonzalez-Brito M, Kuluz JW (2008) Post traumatic brain perfusion SPECT analysis using reconstructed ROI maps of radioactive microsphere derived cerebral blood flow and statistical parametric mapping. BMC.Med.Imaging 8: 4  
www.ncbi.nlm.nih.gov/pubmed/18312639?dopt=Citation

48.  Metting Z, Rodiger LA, De KJ, van der NJ (2007) Structural and functional neuroimaging in mild-to-moderate head injury. Lancet Neurol. 6: 699-710 
www.ncbi.nlm.nih.gov/pubmed/17638611?dopt=Citation

49.  Munson S, Schroth E, Ernst M (2006) The role of functional neuroimaging in pediatric brain injury. Pediatrics 117: 1372-1381  
www.ncbi.nlm.nih.gov/pubmed/16585335?dopt=Citation

50.  Newberg AB, Alavi A (2003) Neuroimaging in patients with head injury. Seminars in Nuclear Medicine 33: 136-147   
www.ncbi.nlm.nih.gov/pubmed/12756646?dopt=Citation

51.  Pavel D, Jobe T, Devore-Best S, Davis G, Epstein P, Sinha S, Kohn R, Craita I, Liu P, Chang Y (2006) Viewing the functional consequences of traumatic brain injury by using brain SPECT. Brain Cogn 60: 211-213 
www.ncbi.nlm.nih.gov/pubmed/16646126?dopt=Citation

52.  Roper SN, Mena I, King WA, Schweitzer J, Garrett K, Mehringer CM, McBride D (1991) An analysis of cerebral blood flow in acute closed-head injury using technetium-99m-HMPAO SPECT and computed tomography. J Nucl Med 32: 1684-1687 
www.ncbi.nlm.nih.gov/pubmed/1880569?dopt=Citation

53.  Shin YB, Kim SJ, Kim IJ, Kim YK, Kim DS, Park JH, Yeom SR (2006) Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: group and individual analyses. Brain Inj. 20: 661-667  
www.ncbi.nlm.nih.gov/pubmed/16754291?dopt=Citation

54.  Silverman IE, Galetta SL, Gray LG, Moster M, Atlas SW, Maurer AH, Alavi A (1993) SPECT in patients with cortical visual loss. J Nucl Med 34: 1447-1451  
www.ncbi.nlm.nih.gov/pubmed/8355062?dopt=Citation

55.  Umile EM, Sandel ME, Alavi A, Terry CM, Plotkin RC (2002) Dynamic imaging in mild traumatic brain injury: support for the theory of medial temporal vulnerability. Arch Phys.Med Rehabil. 83: 1506-1513 
www.ncbi.nlm.nih.gov/pubmed/12422317?dopt=Citation

56.  Van Heertum RL, Drocea C, Ichise M, Lobotesis K, Fawwaz RA (2001) Single photon emission CT and positron emission tomography in the evaluation of neurologic disease. Radiol.Clin North Am 39: 1007-1033   
www.ncbi.nlm.nih.gov/pubmed/11587056?dopt=Citation


Research on Brain SPECT and Carbon Monoxide Poisoning
1.  Borras L, Constant E, De TP, Huguelet P, Khazaal Y (2008) [Long-term psychiatric consequences of carbon monoxide poisoning: A case report and literature review.]. Rev.Med.Interne  
www.ncbi.nlm.nih.gov/pubmed/18571295?dopt=Citation

2. Choi IS, Lee MS (1993) Early hypoperfusion of technetium-99m hexamethylprophylene amine oxime brain single photon emission computed tomography in a patient with carbon monoxide poisoning. European Neurology 33: 461-464
www.ncbi.nlm.nih.gov/pubmed/8307069?dopt=Citation

3.  Chu K, Jung KH, Kim HJ, Jeong SW, Kang DW, Roh JK (2004) Diffusion-weighted MRI and 99mTc-HMPAO SPECT in delayed relapsing type of carbon monoxide poisoning: evidence of delayed cytotoxic edema. European Neurology 51: 98-103   
www.ncbi.nlm.nih.gov/pubmed/14752216?dopt=Citation

4. Denays R, Tondeur M, Noël P, Ham HR (1994) Bilateral cerebral mediofrontal hypoactivity in Tc-99m HMPAO SPECT imaging. Clinical Nuclear Medicine 19: 873-876 
www.ncbi.nlm.nih.gov/pubmed/7805320?dopt=Citation

5.  Denays R, Makhoul E, Dachy B, Tondeur M, Noel P, Ham HR, Mols P (1994) Electroencephalographic mapping and 99mTc HMPAO single-photon emission computed tomography in carbon monoxide poisoning. Annals of Emergency Medicine 24: 947-952
www.ncbi.nlm.nih.gov/pubmed/7978570?dopt=Citation

6.  Gale SD, Hopkins RO, Weaver LK, Bigler ED, Booth EJ, Blatter DD (1999) MRI, quantitative MRI, SPECT, and neuropsychological findings following carbon monoxide poisoning. Brain Inj. 13: 229-243 
www.ncbi.nlm.nih.gov/pubmed/10230524?dopt=Citation

7.  Hopkins RO, Woon FL (2006) Neuroimaging, cognitive, and neurobehavioral outcomes following carbon monoxide poisoning. Behav.Cogn Neurosci.Rev. 5: 141-155
www.ncbi.nlm.nih.gov/pubmed/16891556?dopt=Citation

8.  Kao CH (1998) Fan-beam Tc99m HMPAO brain SPECT in acute carbon monoxide poisoning. Clinical Nuclear Medicine 23: 382   
www.ncbi.nlm.nih.gov/pubmed/9619328?dopt=Citation

9. Lang CJ (2000) The use of neuroimaging techniques for clinical detection of neurotoxicity: a review. Neurotoxicology 21: 847-855  
www.ncbi.nlm.nih.gov/pubmed/11130290?dopt=Citation

10. Maeda Y, Kawasaki Y, Jibinki I, Yamaguchi N, Matsude H, Hisada K (1991) Effect of therapy with oxygen under high pressure on regional cerebral blood flow in the interval form of carbon monoxide poisoning: observation from subtraction of technetium-99m HMPAO SPECT brain imaging. European Neurology 31: 380-383
www.ncbi.nlm.nih.gov/pubmed/1756761?dopt=Citation

11.  Ozyurt G, Kaya FN, Kahveci F, Alper E (2008) Comparison of SPECT findings and neuropsychological sequelae in carbon monoxide and organophosphate poisoning. Clin.Toxicol.(Phila) 46: 218-221    
www.ncbi.nlm.nih.gov/pubmed/18344103?dopt=Citation

12.  Pach D, Hubalewska A, Huszno B, Pach J (2004) Evaluation of regional cerebral perfusion using 99mTc-HmPAO single photon emission tomography (SPET) in carbon monoxide acutely poisoned patients. Przegla¸d lekarski 61: 217-221
www.ncbi.nlm.nih.gov/pubmed/15521570?dopt=Citation

13.  Pach D, Urbanik A, Szczepanska L, Hubalewska A, Huszno B, Groszek B, Jenner B (2005) (99m)Tc-HmPAO single photon emission tomography, magnetic resonance proton spectroscopy and neuropsychological testing in evaluation of carbon monoxide neurotoxicity. Przegla¸d lekarski 62: 441-445
www.ncbi.nlm.nih.gov/pubmed/16225091?dopt=Citation

14.  Parkinson RB, Hopkins RO, Cleavinger HB, Weaver LK, Victoroff J, Foley JF, Bigler ED   (2002) White matter hyperintensities and neuropsychological outcome following carbon monoxide poisoning. Neurology 58: 1523-1532
www.ncbi.nlm.nih.gov/pubmed/12034791?dopt=Citation

15.  Pasquier F, De Poorter MC, Jacquemotte N, Adnet-Bonte C, Petit H (1993) [Cerebellar syndrome after carbon monoxide poisoning. Magnetic resonance imaging and single photon emission tomography]. Revue neurologique (Paris) 149: 805-806
www.ncbi.nlm.nih.gov/pubmed/7997744?dopt=Citation

16.  Romanowski P, Kulakowska A, Drozdowski W (2004) [Neurological disorders after carbon monoxide intoxication]. Pol.Merkur Lekarski. 16: 592-594  
www.ncbi.nlm.nih.gov/pubmed/15510905?dopt=Citation

17. Silverman IE, Galetta SL, Gray LG, Moster M, Atlas SW, Maurer AH, Alavi A (1993) SPECT in patients with cortical visual loss. J Nucl Med 34: 1447-1451 
www.ncbi.nlm.nih.gov/pubmed/8355062?dopt=Citation

18.  Watanabe N, Nohara S, Matsuda H, Sumiya H, Noguchi K, Shimizu M, Tsuji S, Kinuya S, Shuke N, Yokoyama K, Seto H (2002) Statistical parametric mapping in brain single photon computed emission tomography after carbon monoxide intoxication. Nuclear Medicine Communications 23: 355-366 
www.ncbi.nlm.nih.gov/pubmed/11930189?dopt=Citation

19. Wu CI, Changlai SP, Huang WS, Tsai CH, Lee CC, Kao CH (2003) Usefulness of 99mTc ethyl cysteinate dimer brain SPECT to detect abnormal regional cerebral blood flow in patients with acute carbon monoxide poisoning. Nucl.Med.Commun. 24: 1185-1188
www.ncbi.nlm.nih.gov/pubmed/14569173?dopt=Citation

20.  Yu H, Pan X, Meng J, Ding J, Xu G, Fang G (2002) [A clinical study on delayed encephalopathy after carbon monoxide poisoning]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 20: 26-28 
www.ncbi.nlm.nih.gov/pubmed/14694610?dopt=Citation

21.  Zhan HW, Ye XJ, Bao CK, Sun D, Liu QC, He GQ (2005) [Study on cerebral blood flow changes using SPECT imaging on the diagnosis of carbon monoxide poisoning]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 23: 222-223 
www.ncbi.nlm.nih.gov/pubmed/16124909?dopt=Citation

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