Substantive medical research can be extremely valuable in evaluating and treating brain based disorders. As a service to our clients, we have created an extensive bibliography of important research utilizing brain SPECT imaging in the evaluation of brain based disorders. This bibliography is composed of numerous published research article titles, with links to the abstracts, which our medical imaging experts have deemed most significant in assisting you with your brain disorder patients.


ADHD Research
  1. Gustafsson P, Thernlund G, Ryding E, Rosen I, Cederblad M (2000) Associations between cerebral blood-flow measured by single photon emission computed tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms, cognition and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD). Acta paediatrica (Oslo, Norway : 1992) 89: 830-835. http://www.ncbi.nlm.nih.gov/pubmed/1094367
  2. Kaya GC, Pekcanlar A, Bekis R, Ada E, Miral S, Emiroglu N, Durak H (2002) Technetium-99m HMPAO brain SPECT in children with attention deficit hyperactivity disorder. Annals of Nuclear Medicine 16: 527-531. http://www.ncbi.nlm.nih.gov/pubmed/12593417
  3. Kim BN, Lee JS, Cho SC, Lee DS (2001) Methylphenidate increased regional cerebral blood flow in subjects with attention deficit/hyperactivity disorder. Yonsei medical journal 2001 Feb;42(1):19-29: 19-29. http://www.ncbi.nlm.nih.gov/pubmed/11293498
  4. Kim BN, Lee JS, Shin MS, Cho SC, Lee DS (2002) Regional cerebral perfusion abnormalities in attention deficit/hyperactivity disorder. Statistical parametric mapping analysis. European archives of psychiatry and clinical neuroscience 252: 219-225. http://www.ncbi.nlm.nih.gov/pubmed/12451463
  5. Langleben DD, Austin G, Krikorian G, Ridlehuber HW, Goris ML, Strauss HW (2001) Interhemispheric asymmetry of regional cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder. Nuclear Medicine Communications 22: 1333-1340. http://www.ncbi.nlm.nih.gov/pubmed/11711904
  6. Lee JS, Kim BN, Kang E, Lee DS, Kim YK, Chung JK, Lee MC, Cho SC (2005) Regional cerebral blood flow in children with attention deficit hyperactivity disorder: comparison before and after methylphenidate treatment. Human Brain Mapping 24: 157-164. http://www.ncbi.nlm.nih.gov/pubmed/15486990
  7. Lorberboym M, Watemberg N, Nissenkorn A, Nir B, Lerman-Sagie T (2004) Technetium 99m ethylcysteinate dimer single-photon emission computed tomography (SPECT) during intellectual stress test in children and adolescents with pure versus comorbid attention-deficit hyperactivity disorder (ADHD). Journal of Child Neurology 19: 91-96. http://www.ncbi.nlm.nih.gov/pubmed/15072100
  8. Oner O, Oner P, Aysev A, Kucuk O, Ibis E (2005) Regional cerebral blood flow in children with ADHD: changes with age. Brain Dev 27: 279-285. http://www.ncbi.nlm.nih.gov/pubmed/15862191
  9. Pliszka SR, Liotti M, Woldorff MG (2000) Inhibitory control in children with attention-deficit/hyperactivity disorder: event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism. Biol Psychiatry 48: 238-246. http://www.ncbi.nlm.nih.gov/pubmed/10924667
  10. Rohde LA, Roman T, Szobot C, Cunha RD, Hutz MH, Biederman J (2003) Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study. Synapse (New York, N.Y.) 2003 May;48(2):87-9: 87-8. http://www.ncbi.nlm.nih.gov/pubmed/12617042
  11. Sieg KG, Gaffney GR, Preston DF, Hellings JA (2005) SPECT brain imaging abnormalities in attention deficit hyperactivity disorder. Clin Nucl Med. 20: 56-60. http://www.ncbi.nlm.nih.gov/pubmed/7895440
  12. Spalletta G, Pasini A, Pau F, Guido G, Menghini L, Caltagirone C (2001) Prefrontal blood flow dysregulation in drug naive ADHD children without structural abnormalities. J Neural Transm. 108: 1203-1216. http://www.ncbi.nlm.nih.gov/pubmed/11725823
  13. Szobot C, Roman T, Cunha R, Acton P, Hutz M, Rohde LA (2005) Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder. American journal of medical genetics.Part B, Neuropsychiatric genetics 2005 Jan 5;132(1):53-8: 53-58. http://www.ncbi.nlm.nih.gov/pubmed/15389753
  14. Vles JS, Feron FJ, Hendriksen JG, Jolles J, van Kroonenburgh MJ, Weber WE (2003) Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD). Neuropediatrics 34: 77-80. http://www.ncbi.nlm.nih.gov/pubmed/12776228


Anxiety Research
  1. Carey PD, Warwick J, Niehaus DJ, Van der Linden G, van Heerden BB, Harvey BH, Seedat S, Stein DJ (2004) Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram. BMC Psychiatry 4: 30
  2. Conca A, Fritzsche H, Peschina W, König P, Swoboda E, Wiederin H, Haas C (2000) Preliminary findings of simultaneous 18F-FDG and 99mTc-HMPAO SPECT in patients with depressive disorders at rest: differential correlates with ratings of anxiety. Psychiatry Research 98: 43-54
  3. De Cristofaro MT, Sessarego A, Pupi A, Biondi F, Faravelli C (1993) Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study. Biol Psychiatry 33: 505-512
  4. Kaschka W, Feistel H, Ebert D (1995) Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECT. Journal of Psychiatric Research 29: 427-434
  5. Lee YS, Hwang J, Kim SJ, Sung YH, Kim J, Sim ME, Bae SC, Kim MJ, Lyoo IK (2006) Decreased blood flow of temporal regions of the brain in subjects with panic disorder. Journal of Psychiatric Research 40: 528-534
  6. Tankard CF, Waldstein SR, Siegel EL, Holder LE, Lefkowitz D, Anstett F, Katzel LI (2003) Cerebral blood flow and anxiety in older men: an analysis of resting anterior asymmetry and prefrontal regions. Brain and cognition 52: 70-78
  7. Van der Linden G, Van Heerden B, Warwick J, Wessels C, van Kradenburg J, Zungu-Dirwayi N, Stein DJ (2000) Functional brain imaging and pharmacotherapy in social phobia: single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in neuro-psychopharmacology & biological psychiatry 24: 419-438
  8. Woods SW (1992) Regional cerebral blood flow imaging with SPECT in psychiatric disease: focus on schizophrenia, anxiety disorders, and substance abuse. Journal of Clinical Psychiatry 53: 20-25
  9. Eren I, Tukel R, Polat A, Karaman R, Unal S (2003) Evaluation of regional cerebral blood flow changes in panic disorder with Tc99m-HMPAO SPECT. Psychiatry Research 123: 135-143
  10. Malaspina D, Berman A (2000) Psychiatric Disorders. In: Van Heertum RL, Tikofsy RS (eds) Functional Cerebral SPECT and PET Imaging. Lippincott Williams & Wilkins, New York, pp 255-262
  11. Prasko J, Horacek J, Zalesky R, Kopecek M, Novak T, Paskova B, Skrdlantova L, Belohlavek O, Hoschl C (2004) The change of regional brain metabolism (18FDG PET) in panic disorder during the treatment with cognitive behavioral therapy or antidepressants. Neuro.Endocrinol.Lett. 25: 340-348
  12. O'brien JT (2007) Role of imaging techniques in the diagnosis of dementia. Br.J.Radiol. 80 Spec No 2: S71-S77


Bipolar Research
  1. Benabarre A, Vieta E, Martínez-Aràn A, Garcia-Garcia M, Martín F, Lomeña F, Torrent C, Sánchez-Moreno J, Colom F, Reinares M, Brugue E, Valdés M (2005) Neuropsychological disturbances and cerebral blood flow in bipolar disorder. Australian and New Zealand Journal of Psychiatry 39: 227-234. http://www.ncbi.nlm.nih.gov/pubmed/15777358 
  2. Chang K, Adleman NE, Dienes K, Simeonova DI, Menon V, Reiss A (2004) Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Archives of General Psychiatry 61: 781-792. http://www.ncbi.nlm.nih.gov/pubmed/15289277
  3. Goodwin GM, Cavanagh JT, Glabus MF, Kehoe RF, O'Carroll RE, Ebmeier KP (1997) Uptake of 99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: associations with mania. British Journal of Psychiatry 170: 426-430. http://www.ncbi.nlm.nih.gov/pubmed/9307691
  4. Gyulai L, Alavi A, Broich K, Reilley J, Ball WB, Whybrow PC (1997) I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: a clinical study. Biological Psychiatry 41: 152-161. http://www.ncbi.nlm.nih.gov/pubmed/9018385
  5. Mena I, Correa R, Nader A, Boehme V (2004) Bipolar affective disorders: assessment of functional brain changes by means of Tc HMPAO NeuroSPECT. Alasbimn Journal 6(23):January 2004.  http://www2.alasbimnjournal.cl/alasbimn/CDA/sec_b/0,1206,SCID%253D6213,00.html
  6. Migliorelli R, Starkstein SE, Teson A, de Quiros G, Vazquez S, Leiguarda R, Robinson RG (1993) SPECT findings in patients with primary mania. J Neuropsychiatry Clin Neurosci. 5: 379-383. http://www.ncbi.nlm.nih.gov/pubmed/8286935
  7. O'Connell RA, Van Heertum RL, Luck D, Yudd AP, Cueva JE, Billick SB, Cordon DJ, Gersh RJ, Masdeu JC (1995) Single-photon emission computed tomography of the brain in acute mania and schizophrenia. J Neuroimaging 5: 101-104. http://www.ncbi.nlm.nih.gov/pubmed/7718935
  8. Post RM, Speer AM, Hough CJ, Xing G (2003) Neurobiology of bipolar illness: implications for future study and therapeutics. Ann Clin Psychiatry 15: 85-94. http://www.ncbi.nlm.nih.gov/pubmed/12938866


 Dementia Research
  1. Almkvist O, Axelman K, Basun H, Jensen M, Viitanen M, Wahlund LO, Lannfelt L (2003) Clinical findings in nondemented mutation carriers predisposed to Alzheimer's disease: a model of mild cognitive impairment. Acta Neurol.Scand Suppl 179: 77-82. http://www.ncbi.nlm.nih.gov/pubmed/12603253
  2. Bonte FJ, Hom J, Tintner R, Weiner MF (1990) Single photon tomography in Alzheimer's disease and the dementias. Semin.Nucl Med 20: 342-352. http://www.ncbi.nlm.nih.gov/pubmed/12638024
  3. Bonte FJ, Harris TS, Roney CA, Hynan LS (2004) Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign. J Nucl Med 45: 771-774. http://www.ncbi.nlm.nih.gov/pubmed/15136625
  4. Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL III (2006) Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Clin Nucl Med 31: 376-378. http://www.ncbi.nlm.nih.gov/pubmed/16785801
  5. Cappa A, Calcagni ML, Villa G, Giordano A, Marra C, De Rossi G, Puopolo M, Gainotti G (2001) Brain perfusion abnormalities in Alzheimer's disease: comparison between patients with focal temporal lobe dysfunction and patients with diffuse cognitive impairment. Journal of Neurology, Neurosurgery, and Psychiatry 70: 22-27. http://www.ncbi.nlm.nih.gov/pubmed/11118243
  6. Devous MD, Sr. (2002) Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies. Eur.J.Nucl.Med.Mol.Imaging 29: 1685-1696. http://www.ncbi.nlm.nih.gov/pubmed/12458405
  7. Engel P, Cummings JL, Villanueva-Meyer J, Mena I (1993) Single photon emission computed tomography in dementia: relationship of perfusion to cognitive deficits. J Geriatr.Psychiatry Neurol. 6: 144-151. http://www.ncbi.nlm.nih.gov/pubmed/8397758
  8. Golan H, Kremer J, Freedman M, Ichise M (1996) Usefulness of follow-up regional cerebral blood flow measurements by single-photon emission computed tomography in the differential diagnosis of dementia. J Neuroimaging 6: 23-28. http://www.ncbi.nlm.nih.gov/pubmed/8555659
  9. Hanada K, Hosono M, Kudo T, Hitomi Y, Yagyu Y, Kirime E, Komeya Y, Tsujii N, Hitomi K, Nishimura Y (2006) Regional cerebral blood flow in the assessment of major depression and Alzheimer's disease in the early elderly. Nucl Med Commun. 27: 535-541. http://www.ncbi.nlm.nih.gov/pubmed/16710109
  10. Hanyu H, Abe S, Arai H, Asano T, Iwamoto T, Takasaki M (1993) Diagnostic accuracy of single photon emission computed tomography in Alzheimer's disease. Gerontology 39: 260-266. http://www.ncbi.nlm.nih.gov/pubmed/8314092
  11. Huang C, Wahlund LO, Svensson L, Winblad B, Julin P (2002) Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment. BMC Neurology 2:9. http://www.ncbi.nlm.nih.gov/pubmed/12227833
  12. Ishiwata A, Sakayori O, Minoshima S, Mizumura S, Kitamura S, Katayama Y (2006) Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study. Acta Neurol.Scand 114: 91-96. http://www.ncbi.nlm.nih.gov/pubmed/16867030
  13. Jobst KA, Barnetson LP, Shepstone BJ (1998) Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging. Int Psychogeriatr. 10: 271-302. http://www.ncbi.nlm.nih.gov/pubmed/9785148
  14. Johnson KA, Moran EK, Becker JA, Blacker D, Fischman AJ, Albert MS (2007) Single photon emission computed tomography perfusion differences in mild cognitive impairment. J Neurol.Neurosurg.Psychiatry 78: 240-247. http://www.ncbi.nlm.nih.gov/pubmed/17056633
  15. Kogure D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T, Nakano S, Takasaki M (2000) Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT. J Nucl Med 41: 1155-1162. http://www.ncbi.nlm.nih.gov/pubmed/10914904
  16. Matsuda H (2007) Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT. J Nucl Med. http://www.ncbi.nlm.nih.gov/pubmed/17631544
  17. McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT (2003) Dementia with Lewy bodies. Semin.Clin Neuropsychiatry 8: 46-57. http://www.ncbi.nlm.nih.gov/pubmed/12567332
  18. O'brien JT (2007) Role of imaging techniques in the diagnosis of dementia. Br.J.Radiol. 80 Spec No 2: S71-S77. http://www.ncbi.nlm.nih.gov/pubmed/17135460
  19. Osimani A, Ichise M, Chung DG, Pogue JM, Freedman M (1994) SPECT for differential diagnosis of dementia and correlation of rCBF with cognitive impairment. Can.J Neurol.Sci. 21: 104-111. http://www.ncbi.nlm.nih.gov/pubmed/8087734
  20. Starkstein SE, Migliorelli R, Tesón A, Sabe L, Vázquez S, Turjanski M, Robinson RG, Leiguarda R (1994) Specificity of changes in cerebral blood flow in patients with frontal lobe dementia. Journal of Neurology, Neurosurgery, and Psychiatry 57: 790-796. http://www.ncbi.nlm.nih.gov/pubmed/8021663


Depression Research
  1. Austin MP, Dougall N, Ross M, Murray C, O'Carroll RE, Moffoot A, Ebmeier KP, Goodwin GM (1992) Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders 26: 31-43. http://www.ncbi.nlm.nih.gov/pubmed/1430666
  2. Benabarre A, Vieta E, Martín F, Lomeña F, Martínez-Aràn A, Colom F, Corbella B, Gastó C, Valdés M (2004) Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients. Psychiatry Res. 132(3):285-9: 285-289. http://www.ncbi.nlm.nih.gov/pubmed/15664800
  3. Bonne O, Krausz Y, Shapira B, Bocher M, Karger H, Gorfine M, Chisin R, Lerer B (1996) Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. Journal of Nuclear Medicine 37: 1075-1080. http://www.ncbi.nlm.nih.gov/pubmed/8965172
  4. Cho MJ, Lyoo IK, Lee DW, Kwon JS, Lee JS, Lee DS, Jung JK, Lee MC (2002) Brain single photon emission computed tomography findings in depressive pseudodementia patients. J Affect Disord 69: 159-166. http://www.ncbi.nlm.nih.gov/pubmed/12103462
  5. Cummings JL (1993) The neuroanatomy of depression. Journal of Clinical Psychiatry 54: 14-20. http://www.ncbi.nlm.nih.gov/pubmed/8270593
  6. Drevets WC (1999) Prefrontal cortical-amygdalar metabolism in major depression. Ann N Y Acad Sci. 877: 614-637. http://www.ncbi.nlm.nih.gov/pubmed/10415674
  7. Ebert D, Feistel H, Barocka A, Kaschka W, Mokrusch T (1993) A test-retest study of cerebral blood flow during somatosensory stimulation in depressed patients with schizophrenia and major depression. European archives of psychiatry and clinical neuroscience 42: 250-254. http://www.ncbi.nlm.nih.gov/pubmed/8461353
  8. Fountoulakis KN, Iacovides A, Fotiou D, Nimatoudis J, Bascialla F, Ioannidou C, Kaprinis G, Bech P (2004) Neurobiological and psychological correlates of suicidal attempts and thoughts of death in patients with major depression. Neuropsychobiology 49: 42-52. http://www.ncbi.nlm.nih.gov/pubmed/147302000
  9. Gardner A, Pagani M, Jacobsson H, Lindberg G, Larsson SA, Wägner A, Hällstrom T (2002) Differences in resting state regional cerebral blood flow assessed with 99mTc-HMPAO SPECT and brain atlas matching between depressed patients with and without tinnitus. Nuclear Medicine Communications 23: 429-439. http://www.ncbi.nlm.nih.gov/pubmed/11973483
  10. Hanada K, Hosono M, Kudo T, Hitomi Y, Yagyu Y, Kirime E, Komeya Y, Tsujii N, Hitomi K, Nishimura Y (2006) Regional cerebral blood flow in the assessment of major depression and Alzheimer's disease in the early elderly. Nucl Med Commun. 27: 535-541. http://www.ncbi.nlm.nih.gov/pubmed/16710109
  11. Hornig M, Mozley PD, Amsterdam JD (1997) HMPAO SPECT brain imaging in treatment-resistant depression. Progress in Neuro-psychopharmacology and Biological Psychiatry 21: 1097-1114. http://www.ncbi.nlm.nih.gov/pubmed/9421825
  12. Ito H, Kawashima R, Awata S, Ono S, Sato K, Goto R, Koyama M, Sato M, Fukuda H (1996) Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique. Journal of Nuclear Medicine 37: 410-414. http://www.ncbi.nlm.nih.gov/pubmed/8772633
  13. Kanaya T, Yonekawa M (1990) Regional cerebral blood flow in depression. The Japanese journal of psychiatry and neurology 44: 571-576. http://www.ncbi.nlm.nih.gov/pubmed/2074616
  14. Mayberg HS, Lewis PJ, Regenold W, Wagner HN (1994) Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine 35: 929-934. http://www.ncbi.nlm.nih.gov/pubmed/8195877
  15. Prado C, Mena I (1999) Basal and frontal activation neuroSPECT demonstrates functional brain changes in major depression. Alasbimn Journal 1:3. http://www.alasbimnjournal.cl/revistas/3/pradoia.htm
  16. Scott AI, Dougall N, Ross M, O'Carroll RE, Riddle W, Ebmeier KP, Goodwin GM (1994) Short-term effects of electroconvulsive treatment on the uptake of 99mTc-exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders 30: 27-34. http://www.ncbi.nlm.nih.gov/pubmed/8151046
  17. Smith DJ, Cavanagh JT (2005) The use of single photon emission computed tomography in depressive disorders. Nucl Med Commun. 26: 197-203. http://www.ncbi.nlm.nih.gov/pubmed/15722900
  18. Tutus A, Simsek A, Sofuoglu S, Nardali M, Kugu N, Karaaslan F, Gönül AS (1998) Changes in regional cerebral blood flow demonstrated by single photon emission computed tomography in depressive disorders: comparison of unipolar vs. bipolar subtypes. Psychiatry Research 1998 Sep 28;83(3):169-77: 169-177. http://www.ncbi.nlm.nih.gov/pubmed/9849726
  19. Yazici KM, Kapucu O, Erbas B, Varoglu E, Gulec C, Bekdik CF (1992) Assessment of changes in regional cerebral blood flow in patients with major depression using the 99mTc-HMPAO single photon emission tomography method. European Journal of Nuclear Medicine 19: 1038-1043. http://www.ncbi.nlm.nih.gov/pubmed/1464356

OCD Research
  1. Busatto GF, Zamignani DR, Buchpiguel CA, Garrido GE, Glabus MF, Rocha ET, Maia AF, Rosario-Campos MC, Campi Castro C, Furuie SS, Gutierrez MA, McGuire PK, Miguel EC (2000) A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 99: 15-27. http://www.ncbi.nlm.nih.gov/pubmed/10891646 
  2. Busatto GF, Buchpiguel CA, Zamignani DR, Garrido GE, Glabus MF, Rosario-Campos MC, Castro CC, Maia A, Rocha ET, McGuire PK, Miguel EC (2001) Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: an exploratory SPECT study. Journal of the American Academy of Child and Adolescent Psychiatry 2001 Mar;40(3):347-54: 347-354. http://www.ncbi.nlm.nih.gov/pubmed/11288777
  3. Diler RS, Kibar M, Avci A (2004) Pharmacotherapy and regional cerebral blood flow in children with obsessive compulsive disorder. Yonsei medical journal 2004 Feb 29;45(1):90-9: 90-99. http://www.ncbi.nlm.nih.gov/pubmed/15004874
  4. Hendler T, Goshen E, Tadmor R, Lustig M, Zwas ST, Zohar J (1999) Evidence for striatal modulation in the presence of fixed cortical injury in obsessive-compulsive disorder (OCD). European Neuropsychopharmacology 9: 371-376. http://www.ncbi.nlm.nih.gov/pubmed/10523043
  5. Ho Pian KL, van Megen HJ, Ramsey NF, Mandl R, van Rijk PP, Wynne HJ, Westenberg HG (2005) Decreased thalamic blood flow in obsessive-compulsive disorder patients responding to fluvoxamine. Psychiatry Res. 138: 89-97. http://www.ncbi.nlm.nih.gov/pubmed/15766633
  6. Hoehn-Saric R, Schlaepfer TE, Greenberg BD, McLeod DR, Pearlson GD, Wong SH (2001) Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research 108: 89-100. http://www.ncbi.nlm.nih.gov/pubmed/11738543
  7. Lacerda AL, Dalgalarrondo P, Caetano D, Haas GL, Camargo EE, Keshavan MS (2003) Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder. Progress in Neuro-psychopharmacology and Biological Psychiatry 27: 657-665. http://www.ncbi.nlm.nih.gov/pubmed/12787854
  8. Lacerda AL, Dalgalarrondo P, Caetano D, Camargo EE, Etchebehere EC, Soares JC (2003) Elevated thalamic and prefrontal regional cerebral blood flow in obsessive-compulsive disorder: a SPECT study. Psychiatry Res. 123: 125-134. http://www.ncbi.nlm.nih.gov/pubmed/12850251
  9. Topçuoglu V, Cömert B, Karabekiroglu A, Dede F, Erdil TY, Turoglu HT (2005) Right basal ganglion hypoperfusion in obsessive compulsive disorder patients demonstrated by Tc-99m-HMPAO brain perfusion spect: a controlled study. The international journal of neuroscience 2005 Dec;115(12):1643-55: 1643-1655. http://www.ncbi.nlm.nih.gov/pubmed/16287631
   

Stroke Research
  1. Baird AE, Austin MC, McKay WJ, Donnan GA (1997) Sensitivity and specificity of 99mTc-HMPAO SPECT cerebral perfusion measurements during the first 48 hours for the localization of cerebral infarction. Stroke 28: 976-980. http://www.ncbi.nlm.nih.gov/pubmed/915863
  2. Heiss WD, Forsting M, Diener HC (2001) Imaging in cerebrovascular disease. Curr.Opin.Neurol. 14: 67-75. http://www.ncbi.nlm.nih.gov/pubmed/11176220
  3. Leibovitch FS, Black SE, Caldwell CB, Ebert PL, Ehrlich LE, Szalai JP (1998) Brain-behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook Stroke Study. Neurology 50: 901-908. http://www.ncbi.nlm.nih.gov/pubmed/9566370
  4. Lewis DH (1997) Functional brain imaging with cerebral perfusion SPECT in cerebrovascular disease, epilepsy, and trauma. Neurosurg Clin N Am 8: 337-344. http://www.ncbi.nlm.nih.gov/pubmed/9188542
  5. Loutfi I, Singh A (1995) Comparison of quantitative methods for brain single photon emission computed tomography analysis in head trauma and stroke. Invest Radiol. 30: 588-594. http://www.ncbi.nlm.nih.gov/pubmed/8557498
  6. Mena F, Mena I, Ducci H, Soto F, Pedraza L, Contreras A, Miranda M, Basaez E, Fruns M (2004) Tc99m-HMPAO Neuro--SPECT Assessment of Ischemic Penumbra in Acute Brain Infarct: Control of Intra-arterial Thrombolysis Treatment. Alasbimn Journal 7(26):October 2004. http://www2.alasbimnjournal.cl/alasbimn/CDA/sec_b/0,1206,SCID%253D12208,00.html
  7. Mountz JM, Modell JG, Foster NL, DuPree ES, Ackermann RJ, Petry NA, Bluemlein LE, Kuhl DE (1990) Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT. Journal of Nuclear Medicine 31: 61-66. http://www.ncbi.nlm.nih.gov/pubmed/2295942
  8. Mountz JM (2007) Nuclear medicine in the rehabilitative treatment evaluation in stroke recovery. Role of diaschisis resolution and cerebral reorganization. Eura.Medicophys. 43: 221-239. http://www.ncbi.nlm.nih.gov/pubmed/17268387
  9. Sztriha L, al Suhaili AR, Prais V, Nork M (1996) Regional cerebral blood perfusion in children with hemiplegia: A SPECT study. Neuropediatrics 27: 178-183. http://www.ncbi.nlm.nih.gov/pubmed/8892365
  10. Umemura A, Suzuka T, Yamada K (2000) Quantitative measurement of cerebral blood flow by 99mTc-HMPAO SPECT in acute ischaemic stroke: usefulness in determining therapeutic options. Journal of Neurology, Neurosurgery, and Psychiatry 69: 478. http://www.ncbi.nlm.nih.gov/pubmed/10990507 


TBI Research
  1. Abdel-Dayem HM, Abu-Judeh H, Kumar M, Atay S, Naddaf S, El-Zeftawy H, Luo JQ: SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury. Clin Nucl Med 1998;23:309-317. http://www.ncbi.nlm.nih.gov/pubmed/9596157
  2. Abu-Judeh HH, Singh M, Masdeu JC, Abdel-Dayem HM: Discordance between FDG uptake and technetium-99m-HMPAO brain perfusion in acute traumatic brain injury. J Nucl Med 8-1-1998;39:1357-1359. http://www.ncbi.nlm.nih.gov/pubmed/9708506
  3. Abu-Judeh HH, Parker R, Singh M, El-Zeftawy H, Atay S, Kumar M, Naddaf S, Aleksic S, Abdel-Dayem HM: SPECT brain perfusion imaging in mild traumatic brain injury without loss of consciousness and normal computed tomography. Nuclear Medicine Communications 6-1-1999;20:505-510. http://www.ncbi.nlm.nih.gov/pubmed/10451861
  4. Abu-Judeh HH, Parker R, Aleksic S, Singh ML, Naddaf S, Atay S, Kumar M, Omar W, El-Zeftawy H, Luo JQ, Abdel-Dayem HM: SPECT brain perfusion findings in mild or moderate traumatic brain injury. Nucl Med Rev Cent East Eur 4-1-2000;3:5-11. http://www.ncbi.nlm.nih.gov/pubmed/14600973
  5. Agrawal D, Gowda NK, Bal CS, Pant M, Mahapatra AK: Is medial temporal injury responsible for pediatric postconcussion syndrome? A prospective controlled study with single-photon emission computerized tomography. J Neurosurg 2005;102:167-171. http://www.ncbi.nlm.nih.gov/pubmed/16156226
  6. Audenaert K, Jansen HM, Otte A, Peremans K, Vervaet M, Crombez R, de Ridder L, Van Heeringen C, Thirot J, Dierckx R, Korf J: Imaging of mild traumatic brain injury using 57Co and 99mTc HMPAO SPECT as compared to other diagnostic procedures. Med Sci Monit 2003;9:MT112-MT117. http://www.ncbi.nlm.nih.gov/pubmed/14523337
  7. Barkai G, Goshen E, Tzila ZS, Dolberg OT, Pick CG, Bonne O, Schreiber S: Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible. Psychiatry Res 12-30-2004;132:279-283. http://www.ncbi.nlm.nih.gov/pubmed/15664799
  8. Belanger HG, Vanderploeg RD, Curtiss G, Warden DL: Recent neuroimaging techniques in mild traumatic brain injury. J Neuropsychiatry Clin Neurosci 2007;19:5-20. http://www.ncbi.nlm.nih.gov/pubmed/17308222
  9. Bigler ED: Neuroimaging in pediatric traumatic head injury: diagnostic considerations and relationships to neurobehavioral outcome. J Head Trauma Rehabil 1999;14:406-423. http://www.ncbi.nlm.nih.gov/pubmed/10407213
  10. Bigler ED: Neurobiology and neuropathology underlie the neuropsychological deficits associated with traumatic brain injury. Archives of Clinical Neuropsychology 8-1-2003;18:595-621. http://www.ncbi.nlm.nih.gov/pubmed/14591434
  11. Chiu Wong SB, Chapman SB, Cook LG, Anand R, Gamino JF, Devous MD Sr: A SPECT study of language and brain reorganization three years after pediatric brain injury. Prog Brain Res 2006;157:173-185. http://www.ncbi.nlm.nih.gov/pubmed/17167907
  12. Coetzer BR: Obsessive-compulsive disorder following brain injury: a review. International Journal of Psychiatry in Medicine 2004;34:363-377. http://www.ncbi.nlm.nih.gov/pubmed/15825585
  13. Coles JP. Imaging after brain injury. British Journal of Anaesthesia 99 (1), 49-60. 2007. http://www.ncbi.nlm.nih.gov/pubmed/1757339
  14. Davalos DB, Bennett TL: A review of the use of single-photon emission computerized tomography as a diagnostic tool in mild traumatic brain injury. Appl Neuropsychol 2002;9:92-105. http://www.ncbi.nlm.nih.gov/pubmed/12214827
  15. Donnemiller E, Brenneis C, Wissel J, Scherfler C, Poewe W, Riccabona G, Wenning GK: Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPECT study using 123I-beta-CIT and 123I-IBZM. Eur J Nucl Med 2000;27:1410-1414. http://www.ncbi.nlm.nih.gov/pubmed/11007526
  16. Emanuelson IM, von Wendt L, Bjure J, Wiklund LM, Uvebrant P: Computed tomography and single-photon emission computed tomography as diagnostic tools in acquired brain injury among children and adolescents. Developmental Medicine and Child Neurology 8-1-1997;39:502-507.   http://www.ncbi.nlm.nih.gov/pubmed/9295844
  17. Fann JR, Burington B, Lenonetti A, Jaffe K, Katon WJ, Thompson RS: Psychiatric illness following traumatic brain injury in an adult health maintenance organization population. Archives of General Psychiatry 1-1-2004;61:53-61. http://www.ncbi.nlm.nih.gov/pubmed/14706944
  18. Furtak J, Chmielowski K, Podgorski JK, Skrzynski S, Kadlubowski A, Malowidzka-Serwinska M: [Cerebral blood flow changes after mild head trauma imaging with SPECT HMPAO. Preliminary report]. Neurol Neurochir Pol 1995;29:401-407. http://www.ncbi.nlm.nih.gov/pubmed/9045065
  19. Garada B, Klufas RA, Schwartz RB: Neuroimaging in Closed Head Injury. Seminars in Clinical Neuropsychiatry 7-1-1997;2:188-195. http://www.ncbi.nlm.nih.gov/pubmed/10320460
  20. Gerberding JL, Binder S. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem.  9-1-2003.  National Center for Injury Protection & Control. http://www.cdc.gov/ncipc/tbi/mtbi/report.htm
  21. Goethals I, Audenaert K, Jacobs F, Lannoo E, Van de Wiele C, Ham H, Otte A, Oostra K, Dierckx R: Cognitive neuroactivation using SPECT and the Stroop Colored Word Test in patients with diffuse brain injury. Journal of Neurotrauma 8-1-2004;21:1059-1069. http://www.ncbi.nlm.nih.gov/pubmed/15319005
  22. Goshen E, Zwas ST, Shahar E, Tadmor R: The role of 99Tcm-HMPAO brain SPET in paediatric traumatic brain injury. Nuclear Medicine Communications 5-1-1996;17:418-422. http://www.ncbi.nlm.nih.gov/pubmed/8736519
  23. Gowda NK, Agrawal D, Bal C, Chandrashekar N, Tripati M, Bandopadhyaya GP, Malhotra A, Mahapatra AK: Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. AJNR Am J Neuroradiol 2006;27:447-451. http://www.ncbi.nlm.nih.gov/pubmed/16484427
  24. Gray BG, Ichise M, Chung DG, Kirsh JC, Franks W: Technetium-99m-HMPAO SPECT in the evaluation of patients with a remote history of traumatic brain injury: a comparison with x-ray computed tomography. J Nucl Med 1-1-1992;33:52-58. http://www.ncbi.nlm.nih.gov/pubmed/1730996
  25. Harch PG, Fogarty EF, Staab PK, Van MK: Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report. Cases J 2009;2:6538. http://www.ncbi.nlm.nih.gov/pubmed/19829822
  26. Hattori N, Swan M, Stobbe GA, Uomoto JM, Minoshima S, Djang D, Krishnananthan R, Lewis DH: Differential SPECT activation patterns associated with PASAT performance may indicate frontocerebellar functional dissociation in chronic mild traumatic brain injury. J Nucl Med 2009;50:1054-1061. http://www.ncbi.nlm.nih.gov/pubmed/19525460
  27. Ichise M, Chung DG, Wang P, Wortzman G, Gray BG, Franks W: Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance. J Nucl Med 1994;35:217-226. http://www.ncbi.nlm.nih.gov/pubmed/8294988
  28. Ito H, Ishii K, Onuma T, Kawashima R, Fukuda H: Cerebral perfusion changes in traumatic diffuse brain injury; IMP SPECT studies. Annals of Nuclear Medicine 1997;11:167-172. http://www.ncbi.nlm.nih.gov/pubmed/9212901
  29. Jacobs A, Put E, Ingels M, Bossuyt A: Prospective evaluation of technetium-99m-HMPAO SPECT in mild and moderate traumatic brain injury. J Nucl Med 1994;35:942-947. http://www.ncbi.nlm.nih.gov/pubmed/8195879
  30. Jacobs A, Ingels M, Put E, Bossuyt A: One-year follow-up of technetium-99m-HMPAO SPECT in mild head injury. Journal of Nuclear Medicine 10-1-1996;37:1605-1609. http://www.ncbi.nlm.nih.gov/pubmed/8862291
  31. Jorge RE, Robinson RG, Moser D, Tateno A, Crespo-Facorro B, Arndt S: Major depression following traumatic brain injury. Archives of General Psychiatry 1-1-2004;61:42-50. http://www.ncbi.nlm.nih.gov/pubmed/14706943
  32. Kant R, Smith-Seemiller L, Isaac G, Duffy J: Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury: comparison with MRI/CT. Brain Injury 2-1-1997;11:115-124. http://www.ncbi.nlm.nih.gov/pubmed/9012944
  33. Kemp S, Goulding P, Spencer J, Mitchell AJ: Unusually rapid and severe cognitive deterioration after mild traumatic brain injury. Brain Inj 12-20-2005;19:1269-1276. http://www.ncbi.nlm.nih.gov/pubmed/16286343
  34. Korn A, Golan H, Melamed I, Pascual-Marqui R, Friedman A: Focal cortical dysfunction and blood-brain barrier disruption in patients with Postconcussion syndrome. Journal of clinical neurophysiology 2005;221:1-9. http://www.ncbi.nlm.nih.gov/pubmed/15689708
  35. Laatsch L, Jobe T, Sychra J, Lin Q, Blend M: Impact of cognitive rehabilitation therapy on neuropsychological impairments as measured by brain perfusion SPECT: a longitudinal study. Brain Injury 12-1-1997;11:851-863. http://www.ncbi.nlm.nih.gov/pubmed/9413619
  36. Laatsch L, Pavel D, Jobe T, Lin Q, Quintana JC: Incorporation of SPECT imaging in a longitudinal cognitive rehabilitation therapy programme. Brain Injury 8-1-1999;13:555-570. http://www.ncbi.nlm.nih.gov/pubmed/10901685
  37. Lewine JD, Davis JT, Bigler ED, Thoma R, Hill D, Funke M, Sloan JH, Hall S, Orrison WW: Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil 2007;22:141-155. http://www.ncbi.nlm.nih.gov/pubmed/17510590?dopt=Citation
  38. Lewis DH, Bluestone JP, Savina M, Zoller WH, Meshberg EB, Minoshima S: Imaging cerebral activity in recovery from chronic traumatic brain injury: a preliminary report. J Neuroimaging 2006;16:272-277. http://www.ncbi.nlm.nih.gov/pubmed/16808830
  39. Lorberboym M, Lampl Y, Gerzon I, Sadeh M: Brain SPECT evaluation of amnestic ED patients after mild head trauma. The American Journal of Emergency Medicine 7-1-2002;20:310-313. http://www.ncbi.nlm.nih.gov/pubmed/12098178
  40. Lorberboym M, Gilad R, Gorin V, Sadeh M, Lampl Y: Late whiplash syndrome: correlation of brain SPECT with neuropsychological tests and P300 event-related potential. J Trauma 3-1-2002;52:521-526. http://www.ncbi.nlm.nih.gov/pubmed/11901329
  41. Loutfi I, Singh A: Comparison of quantitative methods for brain single photon emission computed tomography analysis in head trauma and stroke. Invest Radiol 1995;30:588-594. http://www.ncbi.nlm.nih.gov/pubmed/8557498
  42. Mann NM, Vento JA: A study comparing SPECT and MRI in patients with anosmia after traumatic brain injury. Clin Nucl Med 2006;31:458-462. http://www.ncbi.nlm.nih.gov/pubmed/16855430
  43. Masdeu JC, Abdel-Dayem H, Van Heertum RL: Head trauma: use of SPECT. Journal of Neuroimaging 1995;5:S53-S57. http://www.ncbi.nlm.nih.gov/pubmed/7626838
  44. Mazzini L, Campini R, Angelino E, Rognone F, Pastore I, Oliveri G: Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome. Arch Phys Med Rehabil 2003;84:1637-1641. http://www.ncbi.nlm.nih.gov/pubmed/14639563
  45. Munson S, Schroth E, Ernst M: The role of functional neuroimaging in pediatric brain injury. Pediatrics 2006;117:1372-1381. http://www.ncbi.nlm.nih.gov/pubmed/16585335
  46. Nedd K, Sfakianakis G, Ganz W, Uricchio B, Vernberg D, Villanueva P, Jabir AM, Bartlett J, Keena J: 99mTc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients: compared with CT--a prospective study. Brain Inj 1993;7:469-479. http://www.ncbi.nlm.nih.gov/pubmed/8260951
  47. Newberg AB, Alavi A: Neuroimaging in patients with head injury. Seminars in Nuclear Medicine 4-1-2003;33:136-147. http://www.ncbi.nlm.nih.gov/pubmed/12756646
  48. Pavel D, Jobe T, Devore-Best S, Davis G, Epstein P, Sinha S, Kohn R, Craita I, Liu P, Chang Y: Viewing the functional consequences of traumatic brain injury by using brain SPECT. Brain Cogn 2006;60:211-213. http://www.ncbi.nlm.nih.gov/pubmed/16646126
  49. Roper SN, Mena I, King WA, Schweitzer J, Garrett K, Mehringer CM, McBride D: An analysis of cerebral blood flow in acute closed-head injury using technetium-99m-HMPAO SPECT and computed tomography. J Nucl Med 9-1-1991;32:1684-1687. http://www.ncbi.nlm.nih.gov/pubmed/1880569
  50. Sheehan W, Thurber S: Review of two years of experiences with SPECT among psychiatric patients in a rural hospital setting. J Psychiatr Pract 2008;14:318-323. http://www.ncbi.nlm.nih.gov/pubmed/18832964
  51. Shin YB, Kim SJ, Kim IJ, Kim YK, Kim DS, Park JH, Yeom SR: Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: group and individual analyses. Brain Inj 2006;20:661-667. http://www.ncbi.nlm.nih.gov/pubmed/16754291
  52. Silverman IE, Galetta SL, Gray LG, Moster M, Atlas SW, Maurer AH, Alavi A: SPECT in patients with cortical visual loss. J Nucl Med 1993;34:1447-1451. http://www.ncbi.nlm.nih.gov/pubmed/8355062
  53. Tatsch K, Asenbaum S, Bartenstein P, Catafau A, Halldin C, Pilowsky LS, Pupi A, European Association of Nuclear Medicine: European Association of Nuclear Medicine procedure guidelines for brain perfusion SPET using (99m)Tc-labelled radiopharmaceuticals. Eur J Nucl Med Mol Imaging 10-1-2002;29:BP36-BP42
  54. Umile EM, Plotkin RC, Sandel ME: Functional assessment of mild traumatic brain injury using SPECT and neuropsychological testing. Brain Inj 7-1-1998;12:577-594. http://www.ncbi.nlm.nih.gov/pubmed/9653521
  55. Umile EM, Sandel ME, Alavi A, Terry CM, Plotkin RC: Dynamic imaging in mild traumatic brain injury: support for the theory of medial temporal vulnerability. Arch Phys Med Rehabil 11-1-2002;83:1506-1513. http://www.ncbi.nlm.nih.gov/pubmed/12422317
  56. Van Heertum RL, Drocea C, Ichise M, Lobotesis K, Fawwaz RA: Single photon emission CT and positron emission tomography in the evaluation of neurologic disease. Radiol Clin North Am 2001;39:1007-1033. http://www.ncbi.nlm.nih.gov/pubmed/11587056

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